In enzymology, a D-lactate dehydrogenase (cytochrome c-553) (EC 1.1.2.5) is an enzyme that catalyzes the chemical reaction

(R)-lactate 2 ferricytochrome c-553 ⇌ {\displaystyle \rightleftharpoons } pyruvate 2 ferrocytochrome c-553

Thus, the two substrates of this enzyme are (R)-lactate and ferricytochrome c-553, whereas its two products are pyruvate and ferrocytochrome c-553.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is (R)-lactate:ferricytochrome-c-553 2-oxidoreductase. This enzyme participates in pyruvate metabolism.

References

  • Ogata M, Arihara K, Yagi T. "D-Lactate dehydrogenase of Desulfovibrio vulgaris". J. Biochem. Tokyo: 1423–1431.



Metabolic pathway of Dlactate production and catabolism. DLactate

DLactate dehydrogenase (EC 1.1.1.28), Leuconostoc mesenteroides

Lactate dehydrogenase molecule Stock Image C035/6375 Science

Cytochrome C oxidase (a) and lactate dehydrogenase (b) activities in

Figure 1 from Targeting lactate dehydrogenaseA promotes docetaxel